While I agree it does not invalidate the study because it is one of the gold standards, it is disingenuous to say that the information provided to gain informed consent in a double blind study has no impact on that study.
You seem to think that a double blind study is to measure the effect of a medication against “no medication”, but it is, in fact, to measure effect against placebo. Double blind is specifically designed to remove experimentator effect in a full consent framework. In fact, the study that are not done with consent, generally in a single blind (the experimentated) are always frowned upon by the community for good reasons.
That does not invalidate a double-blind study.
While I agree it does not invalidate the study because it is one of the gold standards, it is disingenuous to say that the information provided to gain informed consent in a double blind study has no impact on that study.
You seem to think that a double blind study is to measure the effect of a medication against “no medication”, but it is, in fact, to measure effect against placebo. Double blind is specifically designed to remove experimentator effect in a full consent framework. In fact, the study that are not done with consent, generally in a single blind (the experimentated) are always frowned upon by the community for good reasons.
You are missing the point and I won’t restate what was already stated explicitly.